Archive for category Research
Journal of Biological Chemistry: Cordycepin Continues to be an interesting Lead Compound for Cancer Therapy
Cordyceps miltaris and has been proposed as the active component of traditional medication that is reputed to alleviate a large variety of ailments (1,–,3). It has been reported to have numerous biological activities, including the inhibition of cell proliferation (4,–,6), induction of apoptosis (7,–,10), inhibition of platelet aggregation (11), inhibition of cell migration and invasiveness (4, 12), and inhibition of inflammation (13). In mice, cordycepin can reduce tumor formation in a model of metastasis (12) and has therefore been proposed as a cancer drug.
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We all understand the power of living healthy now for a better future. It’s the little things that count. Lately, I’ve been studying up on Asia’s most prized supplement called Cordyceps. If you think back just 5 – 10 years ago there was little talk about Acai, Pomegranate, green tea or raw chocolate. Nobody, really made an effort to make sure they had antioxidants in their diet. Next thing you know some celebrity is talking about her Acai diet, and the guy changing my oil is giving me advice on how to get enough antioxidants in my diet. Get ready to take it up notch by saying that you drink youR acai infused green tea w/ your daily cordyceps…booyah! Cordyceps are well known for thousands of years to strengthen immune system respons and restore youthful vitality. Pharmaceutical companies have found benefits of cordyceps to treat multiple sclerosis.
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From Soup to MS Drug: One Fungus’s Journey
Gilenya, Mitsubishi Tanabe’s parasite-derived pill for multiple sclerosis, could be a blockbuster
Tetsuro Fujita’s eureka moment about a Himalayan fungus came in 1985. As the scientist was driving over a bridge between Japan’s Shikoku and Honshu islands on his way to conduct research on traditional herbal remedies, Fujita was contemplating ways to keep patients’ immune systems from rejecting transplanted organs. He was particularly intrigued by the example of a parasitic fungus used in a Chinese medicinal soup. Known in Asia as “winter insect, summer plant,” the Cordyceps fungus invades an insect larva during winter, feeds on it for months, and then grows out of the host by summer. Fujita suddenly realized that the fungus must be suppressing the immune system of the insect larvae on which it grew to maturity.
His research on Cordyceps at Kyoto University eventually helped Japanese drugmaker Mitsubishi Tanabe Pharma produce Gilenya, a treatment for multiple sclerosis that Novartis (NVS) licensed and began selling in the U.S. in October. UBS (UBS) says annual sales of the medicine, the first pill to treat the autoimmune disease afflicting more than 2 million people worldwide, may exceed $5 billion annually by 2018. That would rank it among the 10 best-selling drugs worldwide, based on data from researcher IMS Health. Mitsubishi Tanabe will likely book royalties equivalent to 10 percent of sales, based on the median of estimates by four analysts surveyed by Bloomberg News.
“Little did I think that it would be a treatment for multiple sclerosis,” says Fujita, 80. “I knew nothing about the disease back then.” Multiple sclerosis causes the immune system to attack the myelin sheath, which protects nerve cells, leading to symptoms including numbness, difficulty in coordination, and memory loss. In its severest form, multiple sclerosis also can shorten life.
Gilenya, approved to treat the relapsing-remitting form of multiple sclerosis, the most common, competes with injected drugs including Biogen Idec’s (BIIB) Avonex and Teva Pharmaceutical Industries’ (TEVA) Copaxone. The Novartis pill cut the number of relapses by more than half compared with Avonex, according to a study published last year in the New England Journal of Medicine.
European regulators are expected to make a decision on the drug by the end of April. Gilenya is also being reviewed by regulators in Japan. In the U.S. the drug is priced at $4,000 for a monthly prescription. A month’s supply of prefilled Avonex syringes costs $2,414.99. Analysts expect Gilenya to be cheaper in Europe.
Current medicines require patients to inject themselves every other day or once a week, says Kyoko Nakata, chairman of Japan’s MS Cabin, a support group. “Gilenya would make it easier to treat the disease, as it saves time and brings patients closer to having a normal life,” says Nakata.
That’s gratifying to Fujita, now a professor emeritus at Kyoto University. “Although it took a quarter of a century,” he says, “I’m happy it’s become a drug while I’m still alive.”
The bottom line: According to analysts’ estimates, Mitsubishi Tanabe will likely book royalties equivalent to 10 percent of sales from its new pill to treat MS.
Matsuyama is a reporter for Bloomberg News.
Preventive Medicine is key to living a healthy lifestyle. Sow the seeds of health now to prevent the surprise of future illnesses. Do it for you and your loved ones. Adding cordyceps to your multi-vitamin regiment can make the difference. It doesn’t hurt to try. Contact Hannah Tran at email@example.com for monthly supply of cordyceps.
“With the help of another researcher, Fujita partnered with Yoshitomi Pharmaceutical Industries Ltd. and Taito Co., now respectively part of Mitsubishi Tanabe and Mitsui Sugar Co. The scientists began studying in 1986 the Cordyceps fungus known in Chinese and Japanese as “winter insect, summer plant,” so called because it invades insect larva during winter and grows out of the host by summer.
Fujita said he was inspired by the discovery of ciclosporin, also derived from a fungus, which spurred research into how the immune system may be subdued in transplant patients. Fujita, now a professor emeritus at Kyoto University, said he was unaware the immune-modulating properties of Cordyceps could eventually help multiple sclerosis patients.“